European Li Fraumeni Foundation

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Prime editing: DNA tool could correct 89% of genetic defects

Source BBCA new way of editing the code of life could correct 89% of the errors in DNA that cause disease, say US scientists.The technology, called prime editing, has been described as a “genetic word processor” able to accurately re-write the genetic code. It has been used to correct damaging mutations in the lab, including those that cause sickle cell […]

What is Li-Fraumeni Syndrome? | Dana-Farber Cancer Institute

E02.1 From Li-Fraumeni syndrome to TP53-related inherited cancers

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If you cannot do great things, do small things in a great way. Napoleon Hill

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“Courage is not the absence of fear, but rather the judgement that something else is more important than fear” ~ Ambrose Redmoon

Emotional Impact of Testing for Li-Fraumeni Syndrome

In general, people who undergo genetic testing for Li-Fraumeni syndrome and are found to have the syndrome do not experience adverse psychological consequences, according to a study published in the Journal of Clinical Oncology. Li-Fraumeni Syndrome (LFS) is a hereditary cancer syndrome. People who have LFS have a high risk of developing various types of cancer. Cancer may develop from […]

Li-Fraumeni Syndrome: Discovery and Future Challenges

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Not Just One, But Many

Some people develop multiple primary tumors throughout their lives and researchers are beginning to tease out why, the Washington Post reports. In some cases, people develop additional primary tumors as a result of the treatment they received for a first cancer, but in other cases, these additional primary tumors are due to genetic variants — such as ones that cause conditions like […]

What is Li Fraumeni?

Li-Fraumeni syndrome  rare, inherited disorder that is caused by mutations (changes) in the TP53 gene. Having Li-Fraumeni syndrome increases the risk of developing many types of cancer. Cancers often develop at an early age, and more than one type of cancer may occur in the same person. Li-Fraumeni syndrome is a type of hereditary cancer syndrome. Also called LFS.
or LFS-like syndrome

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