Li-Fraumeni Syndrome (LFS) is a hereditary cancer syndrome. People who have LFS have a high risk of developing various types of cancer. Cancer may develop from early childhood into adulthood.
Genetic testing for more-common hereditary cancer syndromes (such as those affecting breast and ovarian or colon cancer risk) may have clinical benefit, as individuals at higher risk can take effective preventive measures. For people with LFS, however, preventive options are limited, making the benefit of genetic testing questionable. With questionable—or, at best, limited—benefit to testing for LFS, the psychological impact of undergoing testing is an area of concern.